Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC5441739 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Li Jianchao J Li Jianchao J He Yunyun Y Weck Meredith L ML Lu Qing Q Tyska Matthew J MJ Zhang Mingjie M
Proceedings of the National Academy of Sciences of the United States of America 20170424 19
Unconventional myosin 7a (Myo7a), myosin 7b (Myo7b), and myosin 15a (Myo15a) all contain MyTH4-FERM domains (myosin tail homology 4-band 4.1, ezrin, radixin, moesin; MF) in their cargo binding tails and are essential for the growth and function of microvilli and stereocilia. Numerous mutations have been identified in the MyTH4-FERM tandems of these myosins in patients suffering visual and hearing impairment. Although a number of MF domain binding partners have been identified, the molecular basi ...[more]