Ontology highlight
ABSTRACT:
SUBMITTER: Gruber R
PROVIDER: S-EPMC5441784 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Gruber Ranit R Levitt Michael M Horovitz Amnon A
Proceedings of the National Academy of Sciences of the United States of America 20170501 20
Knowing the mechanism of allosteric switching is important for understanding how molecular machines work. The CCT/TRiC chaperonin nanomachine undergoes ATP-driven conformational changes that are crucial for its folding function. Here, we demonstrate that insight into its allosteric mechanism of ATP hydrolysis can be achieved by Arrhenius analysis. Our results show that ATP hydrolysis triggers sequential ‟conformational waves." They also suggest that these waves start from subunits CCT6 and CCT8 ...[more]