Tea-induced improvement of endothelial function in humans: No role for epigallocatechin gallate (EGCG).

ABSTRACT: Consumption of tea is inversely associated with cardiovascular diseases. However, the active compound(s) responsible for the protective effects of tea are unknown. Although many favorable cardiovascular effects in vitro are mediated by epigallocatechin gallate (EGCG), its contribution to the beneficial effects of tea in vivo remains unresolved. In a randomised crossover study, a single dose of 200?mg EGCG was applied in three different formulas (as green tea beverage, green tea extract (GTE), and isolated EGCG) to 50 healthy men. Flow-mediated dilation (FMD) and endothelial-independent nitro-mediated dilation (NMD) was measured before and two hours after ingestion. Plasma levels of tea compounds were determined after each intervention and correlated with FMD. FMD significantly improved after consumption of green tea containing 200?mg EGCG (p?

SUBMITTER: Lorenz M 

PROVIDER: S-EPMC5442103 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature