Ontology highlight
ABSTRACT:
SUBMITTER: Wagner R
PROVIDER: S-EPMC5442123 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Wagner R R Machann J J Guthoff M M Nawroth P P PP Nadalin S S Saleem M A MA Heyne N N Königsrainer A A Fend F F Schick F F Fritsche A A Stefan N N Häring H-U HU Schleicher E E Siegel-Axel D I DI
Scientific reports 20170523 1
Renal sinus fat (RSF) is a perivascular fat compartment located around renal arteries. In this in vitro and in vivo study we hypothesized that the hepatokine fetuin-A may impair renal function in non alcoholic fatty liver disease (NAFLD) by altering inflammatory signalling in RSF. To study effects of the crosstalk between fetuin-A, RSF and kidney, human renal sinus fat cells (RSFC) were isolated and cocultured with human endothelial cells (EC) or podocytes (PO). RSFC caused downregulation of pro ...[more]