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Diagnostic Accuracy of Ultrasound Scanning for Prenatal Microcephaly in the context of Zika Virus Infection: A Systematic Review and Meta-analysis.


ABSTRACT: To assess the accuracy of ultrasound measurements of fetal biometric parameters for prenatal diagnosis of microcephaly in the context of Zika virus (ZIKV) infection, we searched bibliographic databases for studies published until March 3rd, 2016. We extracted the numbers of true positives, false positives, true negatives, and false negatives and performed a meta-analysis to estimate group sensitivity and specificity. Predictive values for ZIKV-infected pregnancies were extrapolated from those obtained for pregnancies unrelated to ZIKV. Of 111 eligible full texts, nine studies met our inclusion criteria. Pooled estimates from two studies showed that at 3, 4 and 5 standard deviations (SDs)

SUBMITTER: Chibueze EC 

PROVIDER: S-EPMC5442132 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Diagnostic Accuracy of Ultrasound Scanning for Prenatal Microcephaly in the context of Zika Virus Infection: A Systematic Review and Meta-analysis.

Chibueze Ezinne C EC   Parsons Alex J Q AJQ   Lopes Katharina da Silva KDS   Yo Takemoto T   Swa Toshiyuki T   Nagata Chie C   Horita Nobuyuki N   Morisaki Naho N   Balogun Olukunmi O OO   Dagvadorj Amarjargal A   Ota Erika E   Mori Rintaro R   Oladapo Olufemi T OT  

Scientific reports 20170523 1


To assess the accuracy of ultrasound measurements of fetal biometric parameters for prenatal diagnosis of microcephaly in the context of Zika virus (ZIKV) infection, we searched bibliographic databases for studies published until March 3rd, 2016. We extracted the numbers of true positives, false positives, true negatives, and false negatives and performed a meta-analysis to estimate group sensitivity and specificity. Predictive values for ZIKV-infected pregnancies were extrapolated from those ob  ...[more]

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