Ontology highlight
ABSTRACT:
SUBMITTER: Moretti C
PROVIDER: S-EPMC5442469 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Moretti Charlotte C Serrentino Maria-Elisabetta ME Ialy-Radio Côme C Delessard Marion M Soboleva Tatiana A TA Tores Frederic F Leduc Marjorie M Nitschké Patrick P Drevet Joel R JR Tremethick David J DJ Vaiman Daniel D Kocer Ayhan A Cocquet Julie J
Cell death and differentiation 20170505 6
Sperm differentiation requires unique transcriptional regulation and chromatin remodeling after meiosis to ensure proper compaction and protection of the paternal genome. Abnormal sperm chromatin remodeling can induce sperm DNA damage, embryo lethality and male infertility, yet, little is known about the factors which regulate this process. Deficiency in Sly, a mouse Y chromosome-encoded gene expressed only in postmeiotic male germ cells, has been shown to result in the deregulation of hundreds ...[more]