Ontology highlight
ABSTRACT:
SUBMITTER: Da Sacco S
PROVIDER: S-EPMC5442819 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Da Sacco Stefano S Thornton Matthew E ME Petrosyan Astgik A Lavarreda-Pearce Maria M Sedrakyan Sargis S Grubbs Brendan H BH De Filippo Roger E RE Perin Laura L
Stem cells translational medicine 20160909 2
Mature nephrons originate from a small population of uninduced nephrogenic progenitor cells (NPs) within the cap mesenchyme. These cells are characterized by the coexpression of SIX2 and CITED1. Many studies on mouse models as well as on human pluripotent stem cells have advanced our knowledge of NPs, but very little is known about this population in humans, since it is exhausted before birth and strategies for its direct isolation are still limited. Here we report an efficient protocol for dire ...[more]