Ontology highlight
ABSTRACT:
SUBMITTER: Hwang HS
PROVIDER: S-EPMC5443399 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Hwang Hye Suk HS Kim Ki-Hye KH Lee Youri Y Lee Young-Tae YT Ko Eun-Ju EJ Park SooJin S Lee Jong Seok JS Lee Byung-Cheol BC Kwon Young-Man YM Moore Martin L ML Kang Sang-Moo SM
Human vaccines & immunotherapeutics 20170127 5
Vaccine-enhanced disease has been a major obstacle in developing a safe vaccine against respiratory syncytial virus (RSV). This study demonstrates the immunogenicity, efficacy, and safety of virus-like particle (VLP) vaccines containing RSV F (F VLP), G (G VLP), or F and G proteins (FG VLP) in cotton rats. RSV specific antibodies were effectively induced by vaccination of cotton rats with F VLP or FG VLP vaccines. After challenge, lung RSV clearance was observed with RSV F, G, FG VLP, and formal ...[more]