Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations.
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ABSTRACT:
SUBMITTER: Hersman S
PROVIDER: S-EPMC5443779 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations.
Hersman Sarah S Cushman Jesse J Lemelson Noah N Wassum Kate K Lotfipour Shahrdad S Fanselow Michael S MS
Scientific reports 20170524 1
Learning about context is essential for appropriate behavioral strategies, but important contingencies may not arise during initial learning. A variant of contextual fear conditioning, context pre-exposure facilitation, allows us to directly test the relationship between novelty-induced acetylcholine release and later contextual associability. We demonstrate that optogenetically-enhanced acetylcholine during initial contextual exploration leads to stronger fear after subsequent pairing with shoc ...[more]
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