Searching for evidence of genetic mediation of opioid withdrawal by opioid receptor gene polymorphisms.
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ABSTRACT:
SUBMITTER: Jones JD
PROVIDER: S-EPMC5444323 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
Searching for evidence of genetic mediation of opioid withdrawal by opioid receptor gene polymorphisms.
Jones Jermaine D JD Luba Rachel R RR Vogelman Jonathan L JL Comer Sandra D SD
The American journal on addictions 20151221 1
<h4>Background</h4>Previous research has identified many genetic polymorphisms that appear to mediate the effects of opioid drugs. However, the relationship between genetic polymorphisms and the severity of opioid withdrawal has not yet been characterized.<h4>Methods</h4>Data were collected from 48 daily heroin users who previously completed a standardized abstinence-induced or naloxone-precipitated withdrawal procedure to assess opioid dependence. The total withdrawal severity score (based on t ...[more]
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