Ontology highlight
ABSTRACT:
SUBMITTER: Jin WN
PROVIDER: S-EPMC5444553 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Jin Wei-Na WN Shi Samuel Xiang-Yu SX Li Zhiguo Z Li Minshu M Wood Kristofer K Gonzales Rayna J RJ Liu Qiang Q
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20170101 6
Brain ischemia elicits microglial activation and microglia survival depend on signaling through colony-stimulating factor 1 receptor (CSF1R). Although depletion of microglia has been linked to worse stroke outcomes, it remains unclear to what extent and by what mechanisms activated microglia influence ischemia-induced inflammation and injury in the brain. Using a mouse model of transient focal cerebral ischemia and reperfusion, we demonstrated that depletion of microglia via administration of th ...[more]