Structural changes in the COPD lung and related heterogeneity.
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ABSTRACT:
SUBMITTER: Copot D
PROVIDER: S-EPMC5444650 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Structural changes in the COPD lung and related heterogeneity.
Copot Dana D De Keyser Robin R Derom Eric E Ionescu Clara C
PloS one 20170525 5
This paper proposes a mathematical framework for understanding how the structural changes in the COPD lung reflect in model parameters. The core of the analysis is a correlation between the heterogeneity in the lung as COPD degree changes (GOLD II, III and IV) and the nonlinearity index evaluated using the forced oscillation technique. A low frequency evaluation of respiratory impedance models and nonlinearity degree is performed since changes in tissue mechanics are related to viscoelastic prop ...[more]
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