Ontology highlight
ABSTRACT:
SUBMITTER: Giampaolo S
PROVIDER: S-EPMC5444691 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Oncotarget 20170501 18
The role of IL-2 in HSC maintenance is unknown. Here we show that Il2-/- mice develop severe anomalies in HSC maintenance leading to defective hematopoiesis. Whereas, lack of IL-2 signaling was detrimental for lympho- and erythropoiesis, myelopoiesis was enhanced in Il2-/- mice. Investigation of the underlying mechanisms of dysregulated hematopoiesis in Il2-/- mice shows that the IL-2-Treg cell axis is indispensable for HSC maintenance and normal hematopoiesis. Lack of Treg activity resulted in ...[more]