Ontology highlight
ABSTRACT:
SUBMITTER: Teye EK
PROVIDER: S-EPMC5444711 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Teye Emmanuel K EK Sido Abigail A Xin Ping P Finnberg Niklas K NK Gokare Prashanth P Kawasawa Yuka I YI Salzberg Anna C AC Shimko Sara S Bayerl Michael M Ehmann W Christopher WC Claxton David F DF Rybka Witold B WB Drabick Joseph J JJ Wang Hong-Gang HG Abraham Thomas T El-Deiry Wafik S WS Brodsky Robert A RA J Hohl Raymond R Pu Jeffrey J JJ
Oncotarget 20170501 18
Previous studies have linked increased frequency of glycosylphosphatidylinositol-anchor protein (GPI-AP) deficiency with genomic instability and the risk of carcinogenesis. However, the underlying mechanism is still not clear. A randomForest analysis of the gene expression array data from 55 MDS patients (GSE4619) demonstrated a significant (p = 0.0007) correlation (Pearson r =-0.4068) between GPI-anchor biosynthesis gene expression and genomic instability, in which PIGN, a gene participating in ...[more]