Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC5444722 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Li Yong Y Pi Xiang-Ying XY Boland Kelsey K Lad Sonali S Johnson Kelly K Verfaillie Catherine C Morris Rebecca J RJ
Oncotarget 20170501 18
Hmga2 protein, a transcription factor involved in chromatin architecture, is expressed chiefly during development, where it has many key biological functions. When expressed in adult tissues from in various organs, Hmga2 is always related to cancer development. The role of Hmga2 in skin tumorigenesis is, however, not yet understood. We demonstrated that Hmga2 can be found in non-transformed epidermis, specifically located to the membrane of keratinocytes (KCs) in epidermis. Ex vivo culture of KC ...[more]