Ontology highlight
ABSTRACT:
SUBMITTER: Karlsson H
PROVIDER: S-EPMC5444738 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Karlsson Henning H Fryknäs Mårten M Strese Sara S Gullbo Joachim J Westman Gunnar G Bremberg Ulf U Sjöblom Tobias T Pandzic Tatjana T Larsson Rolf R Nygren Peter P
Oncotarget 20170501 18
<h4>Background</h4>The thiosemicarbazone CD 02750 (VLX50) was recently reported as a hit compound in a phenotype-based drug screen in primary cultures of patient tumor cells. We synthesized a copper complex of VLX50, denoted VLX60, and characterized its antitumor and mechanistic properties.<h4>Materials and methods</h4>The cytotoxic effects and mechanistic properties of VLX60 were investigated in monolayer cultures of multiple human cell lines, in tumor cells from patients, in a 3-D spheroid cel ...[more]