Ontology highlight
ABSTRACT:
SUBMITTER: Liao Y
PROVIDER: S-EPMC5444742 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Liao Yunfei Y Chen Lulu L Feng Yong Y Shen Jacson J Gao Yan Y Cote Gregory G Choy Edwin E Harmon David D Mankin Henry H Hornicek Francis F Duan Zhenfeng Z
Oncotarget 20170501 18
Programmed cell death ligand 1 (PD-L1) is a transmembrane protein that is expressed on tumor cells that suppresses the T cell-mediated immune response. Therapies targeting the PD-L1 pathway promote anti-tumor immunity and have shown promising results in some types of cancers. However, the functional and therapeutic roles of PD-L1 in osteosarcoma remain largely unknown. In this study, we found that PD-L1 protein was expressed in osteosarcoma cell lines and tissue microarray of patient tumors. Tis ...[more]