Ontology highlight
ABSTRACT:
SUBMITTER: Nag S
PROVIDER: S-EPMC5445084 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Nag Sidsel S Nag Sidsel S Dalgaard Marlene D MD Kofoed Poul-Erik PE Ursing Johan J Crespo Marina M Andersen Lee O'Brien LO Aarestrup Frank Møller FM Lund Ole O Alifrangis Michael M
Scientific reports 20170525 1
Genetic polymorphisms in P. falciparum can be used to indicate the parasite's susceptibility to antimalarial drugs as well as its geographical origin. Both of these factors are key to monitoring development and spread of antimalarial drug resistance. In this study, we combine multiplex PCR, custom designed dual indexing and Miseq sequencing for high throughput SNP-profiling of 457 malaria infections from Guinea-Bissau, at the cost of 10 USD per sample. By amplifying and sequencing 15 genetic fra ...[more]