Ontology highlight
ABSTRACT:
SUBMITTER: Gall T
PROVIDER: S-EPMC5445140 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Frontiers in medicine 20170526
Traditionally, the use of genomic information for personalized medical decisions relies on prior discovery and validation of genotype-phenotype associations. This approach constrains care for patients presenting with undescribed problems. The National Institutes of Health (NIH) Undiagnosed Diseases Program (UDP) hypothesized that defining disease as maladaptation to an ecological niche allows delineation of a logical framework to diagnose and evaluate such patients. Herein, we present the philos ...[more]