Dataset Information

Euvolemic hyponatremia in cancer patients. Report of the Hyponatremia Registry: an observational multicenter international study.

ABSTRACT:

Purpose

Hyponatremia secondary to SIADH is frequent in cancer patients and potentially deleterious. The aim of this sub-analysis of the Hyponatremia Registry database is to analyze current diagnostic and therapeutic management practices in cancer patients with SIADH.

Methods

We analyzed 358 cancer patients who had serum sodium concentration ([Na⁺]) ? 130 mEq/L and a clinical diagnosis of SIADH from 225 sites in the USA and EU.

Results

Precise diagnostic testing was performed in only 46%. Almost 12% of all patients did not receive any hyponatremia treatment. The most frequent therapies were fluid restriction (20%), isotonic saline (14%), fluid restriction/isotonic saline (7%), tolvaptan (8%), and salt tablets (7%). Hypertonic saline was used in less than 3%. Tolvaptan produced the greatest median rate of [Na⁺] change (IQR) (3.0 (4.7) mEq/L/day), followed by hypertonic saline (2.0(7.0) mEq/L/day), and fluid restriction/isotonic saline (1.9(3.2) mEq/L/day). Both fluid restriction and isotonic saline monotherapies were significantly less effective (0.8(2.0) mEq/L/day and 1.3(3.0) mEq/L/day, respectively) and were associated with clinically relevant rates of treatment failure. Only 46% of patients were discharged with [Na⁺] ? 130 mEq/L. Overly rapid correction of hyponatremia occurred in 11.7%.

Conclusions

Although essential for successful hyponatremia management, appropriate diagnostic testing is not routinely performed in current practice. The most frequently employed monotherapies were often ineffective and sometimes even aggravated hyponatremia. Tolvaptan was used less often but showed significantly greater effectiveness. Despite clear evidence that hyponatremia is associated with poor outcome in oncology patients, most patients were discharged still hyponatremic. Further studies are needed to assess the beneficial impact of hyponatremia correction with effective therapies.

SUBMITTER: Burst V

PROVIDER: S-EPMC5445151 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Publications

Euvolemic hyponatremia in cancer patients. Report of the Hyponatremia Registry: an observational multicenter international study.

Burst Volker V Grundmann Franziska F Kubacki Torsten T Greenberg Arthur A Rudolf Despina D Salahudeen Abdulla A Verbalis Joseph J Grohé Christian C

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20170302 7

<h4>Purpose</h4>Hyponatremia secondary to SIADH is frequent in cancer patients and potentially deleterious. The aim of this sub-analysis of the Hyponatremia Registry database is to analyze current diagnostic and therapeutic management practices in cancer patients with SIADH.<h4>Methods</h4>We analyzed 358 cancer patients who had serum sodium concentration ([Na<sup>+</sup>]) ≤ 130 mEq/L and a clinical diagnosis of SIADH from 225 sites in the USA and EU.<h4>Results</h4>Precise diagnostic testing w ...[more]

PMID: 28255808

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Project description:BackgroundESMO COVID-19 and CAncer REgistry (ESMO-CoCARE) is an international collaborative registry-based, cohort study gathering real-world data from Europe, Asia/Oceania and Africa on the natural history, management and outcomes of patients with cancer infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).Patients and methodsESMO-CoCARE captures information on patients with solid/haematological malignancies, diagnosed with coronavirus disease 2019 (COVID-19). Data collected since June 2020 include demographics, comorbidities, laboratory measurements, cancer characteristics, COVID-19 clinical features, management and outcome. Parameters influencing COVID-19 severity/recovery were investigated as well as factors associated with overall survival (OS) upon SARS-CoV-2 infection.ResultsThis analysis includes 1626 patients from 20 countries (87% from 24 European, 7% from 5 North African, 6% from 8 Asian/Oceanian centres), with COVID-19 diagnosis from January 2020 to May 2021. Median age was 64 years, with 52% of female, 57% of cancer stage III/IV and 65% receiving active cancer treatment. Nearly 64% patients required hospitalization due to COVID-19 diagnosis, with 11% receiving intensive care. In multivariable analysis, male sex, older age, Eastern Cooperative Oncology Group (ECOG) performance status ≥2, body mass index (BMI) <25 kg/m2, presence of comorbidities, symptomatic disease, as well as haematological malignancies, active/progressive cancer, neutrophil-to-lymphocyte ratio (NLR) ≥6 and OnCovid Inflammatory Score ≤40 were associated with COVID-19 severity (i.e. severe/moderate disease requiring hospitalization). About 98% of patients with mild COVID-19 recovered, as opposed to 71% with severe/moderate disease. Advanced cancer stage was an additional adverse prognostic factor for recovery. At data cut-off, and with median follow-up of 3 months, the COVID-19-related death rate was 24.5% (297/1212), with 380 deaths recorded in total. Almost all factors associated with COVID-19 severity, except for BMI and NLR, were also predictive of inferior OS, along with smoking and non-Asian ethnicity.ConclusionsSelected patient and cancer characteristics related to sex, ethnicity, poor fitness, comorbidities, inflammation and active malignancy predict for severe/moderate disease and adverse outcomes from COVID-19 in patients with cancer.

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Dataset Information

Euvolemic hyponatremia in cancer patients. Report of the Hyponatremia Registry: an observational multicenter international study.

Purpose

Methods

Results

Conclusions

Publications

Euvolemic hyponatremia in cancer patients. Report of the Hyponatremia Registry: an observational multicenter international study.

Similar Datasets

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