Unknown

Dataset Information

0

The atherogenic index of plasma and the risk of mortality in incident dialysis patients: Results from a nationwide prospective cohort in Korea.


ABSTRACT:

Background

The atherogenic index of plasma (AIP), which is the logarithmic ratio of triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C), had a linear relationship with clinical outcomes in the general population. However, the association of each lipid profile, TG and HDL-C, with survival was not straightforward in dialysis patients. This non-linear association led us to further investigate the prognostic impact of the AIP in these patients.

Methods

From a nationwide prospective cohort, 1,174 incident dialysis patients were included. Patients were categorized into quintiles according to the AIP. An independent association of the AIP with all-cause and cardiovascular mortality was determined.

Results

During a mean follow-up duration of 33.2 months, 170 patients (14.5%) died, and cardiovascular death was observed in 55 patients (4.7%). Multivariate Cox analyses revealed that the lowest (quintile 1, hazard ratio [HR] = 1.76, 95% confidence interval [CI] = 1.02-3.03) and the highest (quintile 5, HR = 2.15, 95% CI = 1.26-3.65) AIP groups were significantly associated with higher all-cause mortality compared to patients in quintile 3 (reference group). In terms of cardiovascular mortality, only the highest AIP group (quintile 5, HR = 2.59, 95% CI = 1.06-6.34) was significantly associated with increased risk of mortality. Sensitivity analyses showed that a U-shaped association between the AIP and all-cause mortality remained significant in non-diabetic and underweight to normal body mass index patients.

Conclusions

Both the highest and the lowest AIP groups were independently associated with all-cause mortality, showing a U-shaped association. It suggested further studies are needed to identify targets and subgroups that can benefit from intervention of the AIP in incident dialysis patients.

SUBMITTER: Lee MJ 

PROVIDER: S-EPMC5446226 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

altmetric image

Publications

The atherogenic index of plasma and the risk of mortality in incident dialysis patients: Results from a nationwide prospective cohort in Korea.

Lee Mi Jung MJ   Park Jung Tak JT   Han Seung Hyeok SH   Kim Yong-Lim YL   Kim Yon Su YS   Yang Chul Woo CW   Kim Nam-Ho NH   Kang Shin-Wook SW   Kim Hyung Jong HJ   Yoo Tae-Hyun TH  

PloS one 20170526 5


<h4>Background</h4>The atherogenic index of plasma (AIP), which is the logarithmic ratio of triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C), had a linear relationship with clinical outcomes in the general population. However, the association of each lipid profile, TG and HDL-C, with survival was not straightforward in dialysis patients. This non-linear association led us to further investigate the prognostic impact of the AIP in these patients.<h4>Methods</h4>From a nationwide  ...[more]

Similar Datasets

| S-EPMC4839943 | biostudies-literature
| S-EPMC3875495 | biostudies-literature
| S-EPMC5338775 | biostudies-literature
| S-EPMC4267775 | biostudies-literature
| S-EPMC3886735 | biostudies-literature
| S-EPMC9235232 | biostudies-literature
| S-EPMC9158358 | biostudies-literature
| S-EPMC7430005 | biostudies-literature
| S-EPMC10250605 | biostudies-literature
| S-EPMC6960040 | biostudies-literature