Mathematical modeling of gonadotropin-releasing hormone signaling.
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ABSTRACT:
SUBMITTER: Pratap A
PROVIDER: S-EPMC5446263 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
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Mathematical modeling of gonadotropin-releasing hormone signaling.
Pratap Amitesh A Garner Kathryn L KL Voliotis Margaritis M Tsaneva-Atanasova Krasimira K McArdle Craig A CA
Molecular and cellular endocrinology 20160817
Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary gonadotropes to control reproduction. These are G<sub>q</sub>-coupled receptors that mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the chronic regulation of their synthesis. GnRH is secreted in short pulses and GnRH effects on its target cells are dependent upon the dynamics of these pulses. Here we overview GnRH recept ...[more]
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