Ontology highlight
ABSTRACT:
SUBMITTER: McBean GJ
PROVIDER: S-EPMC5446580 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
McBean G J GJ López M G MG Wallner F K FK
British journal of pharmacology 20160825 12
This review describes recent developments in the search for effective therapeutic agents that target redox homeostasis in neurodegenerative disease. The disruption to thiol redox homeostasis in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and multiple sclerosis is discussed, together with the experimental strategies that are aimed at preventing, or at least minimizing, oxidative damage in these diseases. Particular attention is given to the potential of increasing anti ...[more]