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A methodology for elucidating regulatory mechanisms leading to changes in lipid profiles.

ABSTRACT: It is difficult to elucidate the metabolic and regulatory factors causing lipidome perturbations.This work simplifies this process.A method has been developed to query an online holistic lipid metabolic network (of 7923 metabolites) to extract the pathways that connect the input list of lipids.The output enables pathway visualisation and the querying of other databases to identify potential regulators. When used to a study a plasma lipidome dataset of polycystic ovary syndrome, 14 enzymes were identified, of which 3 are linked to ELAVL1-an mRNA stabiliser.This method provides a simplified approach to identifying potential regulators causing lipid-profile perturbations.

SUBMITTER: Casbas Pinto F

PROVIDER: S-EPMC5447331 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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A methodology for elucidating regulatory mechanisms leading to changes in lipid profiles.

Casbas Pinto Ferran F Ravipati Srinivarao S Barrett David A DA Hodgman T Charles TC

Metabolomics : Official journal of the Metabolomic Society 20170529 7

<h4>Introduction</h4>It is difficult to elucidate the metabolic and regulatory factors causing lipidome perturbations.<h4>Objectives</h4>This work simplifies this process.<h4>Methods</h4>A method has been developed to query an online holistic lipid metabolic network (of 7923 metabolites) to extract the pathways that connect the input list of lipids.<h4>Results</h4>The output enables pathway visualisation and the querying of other databases to identify potential regulators. When used to a study a ...[more]

PMID: 28596719

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