AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System.
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ABSTRACT:
SUBMITTER: Salt IP
PROVIDER: S-EPMC5447810 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
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AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System.
Salt Ian P IP Hardie D Grahame DG
Circulation research 20170501 11
The AMP-activated protein kinase (AMPK) is a key regulator of cellular and whole-body energy homeostasis, which acts to restore energy homoeostasis whenever cellular energy charge is depleted. Over the last 2 decades, it has become apparent that AMPK regulates several other cellular functions and has specific roles in cardiovascular tissues, acting to regulate cardiac metabolism and contractile function, as well as promoting anticontractile, anti-inflammatory, and antiatherogenic actions in bloo ...[more]
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