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Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases.

ABSTRACT: RNA interference (RNAi), including microRNAs, is an important player in the mediation of differentiation and migration of stem cells via target genes. It is used as a potential strategy for gene therapy for central nervous system (CNS) diseases. Stem cells are considered vectors of RNAi due to their capacity to deliver RNAi to other cells. In this review, we discuss the recent advances in studies of RNAi pathways in controlling neuronal differentiation and migration of stem cells. We also highlight the utilization of a combination of RNAi and stem cells in treatment of CNS diseases.

SUBMITTER: Hou XQ

PROVIDER: S-EPMC5448009 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases.

Hou Xue-Qin XQ Wang Lei L Wang Fu-Gang FG Zhao Xiao-Min XM Zhang Han-Ting HT

Genes 20170506 5

RNA interference (RNAi), including microRNAs, is an important player in the mediation of differentiation and migration of stem cells via target genes. It is used as a potential strategy for gene therapy for central nervous system (CNS) diseases. Stem cells are considered vectors of RNAi due to their capacity to deliver RNAi to other cells. In this review, we discuss the recent advances in studies of RNAi pathways in controlling neuronal differentiation and migration of stem cells. We also highli ...[more]

PMID: 28481269

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