Ontology highlight
ABSTRACT:
SUBMITTER: Lesbats P
PROVIDER: S-EPMC5448199 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Lesbats Paul P Serrao Erik E Maskell Daniel P DP Pye Valerie E VE O'Reilly Nicola N Lindemann Dirk D Engelman Alan N AN Cherepanov Peter P
Proceedings of the National Academy of Sciences of the United States of America 20170510 21
The interactions between a retrovirus and host cell chromatin that underlie integration and provirus expression are poorly understood. The prototype foamy virus (PFV) structural protein GAG associates with chromosomes via a chromatin-binding sequence (CBS) located within its C-terminal region. Here, we show that the PFV CBS is essential and sufficient for a direct interaction with nucleosomes and present a crystal structure of the CBS bound to a mononucleosome. The CBS interacts with the histone ...[more]