Ontology highlight
ABSTRACT:
SUBMITTER: Fan J
PROVIDER: S-EPMC5448201 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Fan Jianguo J Jia Li L Li Yan Y Ebrahim Seham S May-Simera Helen H Wood Alynda A Morell Robert J RJ Liu Pinghu P Lei Jingqi J Kachar Bechara B Belluscio Leonardo L Qian Haohua H Li Tiansen T Li Wei W Wistow Graeme G Dong Lijin L
Proceedings of the National Academy of Sciences of the United States of America 20170508 21
The polycistronic miR-183/96/182 cluster is preferentially and abundantly expressed in terminally differentiating sensory epithelia. To clarify its roles in the terminal differentiation of sensory receptors in vivo, we deleted the entire gene cluster in mouse germline through homologous recombination. The miR-183/96/182 null mice display impairment of the visual, auditory, vestibular, and olfactory systems, attributable to profound defects in sensory receptor terminal differentiation. Maturation ...[more]