Ontology highlight
ABSTRACT:
SUBMITTER: Sun X
PROVIDER: S-EPMC5448536 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Sun Xiaoguang X Mathew Biji B Sammani Saad S Jacobson Jeffrey R JR Garcia Joe G N JGN
Pulmonary circulation 20170321 1
We have demonstrated that simvastatin and sphingosine 1-phosphate (S1P) both attenuate increased vascular permeability in preclinical models of acute respiratory distress syndrome. However, the underlying mechanisms remain unclear. As Krüppel-like factor 2 (KLF2) serves as a critical regulator for cellular stress response in endothelial cells (EC), we hypothesized that simvastatin enhances endothelial barrier function via increasing expression of the barrier-promoting S1P receptor, <i>S1PR1</i>, ...[more]