Ontology highlight
ABSTRACT:
SUBMITTER: Kasai Y
PROVIDER: S-EPMC5448622 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Kasai Yosuke Y Toriguchi Kan K Hatano Etsuro E Nishi Kiyoto K Ohno Mikiko M Yoh Tomoaki T Fukuyama Keita K Nishio Takahiro T Okuno Masayuki M Iwaisako Keiko K Seo Satoru S Taura Kojiro K Kurokawa Masato M Kunichika Makoto M Uemoto Shinji S Nishi Eiichiro E
Cancer science 20170424 5
Nardilysin (NRDC) is a metalloendopeptidase of the M16 family. We previously showed that NRDC activates inflammatory cytokine signaling, including interleukin-6-signal transducer and activator of transcription 3 (STAT3) signaling. NRDC has been implicated in the promotion of breast, gastric and esophageal cancer, as well as the development of liver fibrosis. In this study, we investigated the role of NRDC in the promotion of hepatocellular carcinoma (HCC), both clinically and experimentally. We ...[more]