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Intraoperative peritoneal lavage cytology offers prognostic significance for gastric cancer patients with curative resection.

ABSTRACT: Outcomes of patients with gastric cancer who exhibit positive peritoneal lavage cytology findings (CY⁺ ) vary by diagnostic methods because of quantitative and qualitative cancer cell diversity. This study sought to establish practical diagnostic criteria for performing curative resections, based on peritoneal lavage cytology findings in gastric cancer patients. We enrolled 1028 patients with gastric cancer who underwent R0/1 (n = 911) or R2 (n = 117) resections and analyzed relationships between cancer cell findings in peritoneal lavage fluid and clinicopathological factors in the R0/1 group. We found 68 patients with CY⁺ status. Receiver operating characteristic analyses and multivariate analyses showed that the presence of ?1 signet ring cell, ?5 cell clusters or ?50 isolated cancer cells in peritoneal lavage fluid predicted poor prognoses in the 68 CY⁺ patients. High-risk CY⁺ group patients with at least one of the above predictors had the highest hazard ratio (HR = 3.28, P < 0.001). The remaining (low-risk) patients had a survival curve similar to that of patients with a normal cytology. The high-risk CY⁺ patients who underwent R1 resection had poor prognoses despite no macroscopic peritoneal metastasis (2% 5-year survival)-equivalent to that of patients who underwent R2 resection. The CY⁺ criteria defined in this study could help identify candidates for curative resection as an initial therapy for gastric cancer.

SUBMITTER: Higaki E

PROVIDER: S-EPMC5448654 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Intraoperative peritoneal lavage cytology offers prognostic significance for gastric cancer patients with curative resection.

Higaki Eiji E Higaki Eiji E Yanagi Shinya S Gotohda Naoto N Kinoshita Takahiro T Kuwata Takeshi T Nagino Masato M Ochiai Atsushi A Fujii Satoshi S

Cancer science 20170522 5

Outcomes of patients with gastric cancer who exhibit positive peritoneal lavage cytology findings (CY<sup>+</sup> ) vary by diagnostic methods because of quantitative and qualitative cancer cell diversity. This study sought to establish practical diagnostic criteria for performing curative resections, based on peritoneal lavage cytology findings in gastric cancer patients. We enrolled 1028 patients with gastric cancer who underwent R0/1 (n = 911) or R2 (n = 117) resections and analyzed relations ...[more]

PMID: 28256061

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Project description:Background and aimColorectal cancer (CRC) accounts for over 8% of all deaths each year, with 1.2 million new cases diagnosed annually worldwide. It represents the seventh most common cancer in Egypt. Early detection of peritoneal metastasis is a major challenge in such cases. It helps with the decision of the immediate application of intraperitoneal chemotherapy after resection. Meta-analysis studies reported contrast evidence for a possible prognostic role of intraperitoneal free cancer cells (IPCCs) in peritoneal recurrence and survival after curative resection. In this work, we aim to evaluate the prevalence and impact of detecting free malignant cells in peritoneal fluid on survival and local recurrence and to estimate the incidence of peritoneal carcinomatosis (PC) during follow up.MethodsDesign: This was a prospective cohort study. Settings: From June 2016 to December 2018, samples were collected from 104 patients who underwent abdominal surgery for colorectal cancer in the Egyptian National Cancer Institute. A total of 96 Egyptian CRC patients who underwent curative resection were enrolled. Intraoperative peritoneal lavage was performed to detect IPCC by conventional cytology. Patients with no residual tumor after surgery and no evidence of PC were followed up for a median 14 months. The cumulative 12-month overall survival rate for patients with IPCC was 100% versus 86% for patients with negative cytology.ResultsOur results demonstrated that the prevalence of IPCC in the peritoneal lavage was 11.5%. Peritoneal and local recurrence occurred at a higher rate in patients with cytology positive lavage (9.1% vs 6.3% and 9.1% vs 3.8%, respectively), although this was statistically insignificant. Distant metastasis occurred significantly in patients with positive cytology (45.5% vs 8.9%) with P-value <0.001.The conventional cytology technique has a high specificity but less sensitivity.ConclusionsThe presence of IPCC using conventional cytology was not an independent prognostic factor for the development of PC or survival.

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Intraoperative peritoneal lavage cytology offers prognostic significance for gastric cancer patients with curative resection.

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Intraoperative peritoneal lavage cytology offers prognostic significance for gastric cancer patients with curative resection.

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