Leucine-rich glioma inactivated 3: integrative analyses support its prognostic role in glioma.

ABSTRACT:

Background

Leucine-rich glioma inactivated 3 (LGI3) is a secreted protein member of LGI family. We previously reported that LGI3 was expressed in brain, adipose tissues and skin, where it played roles as a multifunctional cytokine. We postulated that LGI3 may be involved in cytokine network in cancers.

Aim

This study aimed to analyze differentially expressed genes in glioma tissues and glioma cohort data to investigate the prognostic role of LGI3 and its receptors.

Materials and methods

Expression microarray data from Gene Expression Omnibus and glioma cohort data were analyzed using bioinformatic tools for statistical analysis, protein-protein interactions, functional enrichment and pathway analyses and prognostic association analysis.

Results

We found that LG

SUBMITTER: Kwon NS 

PROVIDER: S-EPMC5449096 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature