Ontology highlight
ABSTRACT:
SUBMITTER: Wali S
PROVIDER: S-EPMC5449249 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Wali Shradha S Gupta Rishein R Yu Jieh-Juen JJ Lanka Gopala Krishna Koundinya GKK Chambers James P JP Guentzel M Neal MN Zhong Guangming G Murthy Ashlesh K AK Arulanandam Bernard P BP
Immunology and cell biology 20161219 5
We have comprehensively demonstrated using the mouse model that intranasal immunization with recombinant chlamydial protease-like activity factor (rCPAF) leads to a significant reduction in bacterial burden, genital tract pathology and preserves fertility following intravaginal genital chlamydial challenge. In the present report, we evaluated the protective efficacy of rCPAF immunization in guinea pigs, a second animal model for genital chlamydial infection. Using a vaccination strategy similar ...[more]