Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior.
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ABSTRACT:
SUBMITTER: LeBlanc BW
PROVIDER: S-EPMC5449396 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior.
LeBlanc Brian W BW Cross Brent B Smith Kelsey A KA Roach Catherine C Xia Jimmy J Chao Yu-Chieh YC Levitt Joshua J Koyama Suguru S Moore Christopher I CI Saab Carl Y CY
Scientific reports 20170530 1
We tested the relation between pain behavior, theta (4-8 Hz) oscillations in somatosensory cortex and burst firing in thalamic neurons in vivo. Optically-induced thalamic bursts attenuated cortical theta and mechanical allodynia. It is proposed that thalamic bursts are an adaptive response to pain that de-synchronizes cortical theta and decreases sensory salience. ...[more]
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