Mechanisms of Autoantibody-Induced Pathology.
Ontology highlight
ABSTRACT:
SUBMITTER: Ludwig RJ
PROVIDER: S-EPMC5449453 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Mechanisms of Autoantibody-Induced Pathology.
Ludwig Ralf J RJ Vanhoorelbeke Karen K Leypoldt Frank F Kaya Ziya Z Bieber Katja K McLachlan Sandra M SM Komorowski Lars L Luo Jie J Cabral-Marques Otavio O Hammers Christoph M CM Lindstrom Jon M JM Lamprecht Peter P Fischer Andrea A Riemekasten Gabriela G Tersteeg Claudia C Sondermann Peter P Rapoport Basil B Wandinger Klaus-Peter KP Probst Christian C El Beidaq Asmaa A Schmidt Enno E Verkman Alan A Manz Rudolf A RA Nimmerjahn Falk F
Frontiers in immunology 20170531
Autoantibodies are frequently observed in healthy individuals. In a minority of these individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis or Graves' disease. Overall, more than 2.5% of the population is affected by autoantibody-driven autoimmune disease. Pathways leading to autoantibody-induced pathology greatly differ among different diseases, and autoantibodies directed against the same antigen, depending on the targeted epitope, can have diverse effect ...[more]
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