Association of complement factor H tyrosine 402 histidine genotype with posterior involvement in sarcoid-related uveitis.

ABSTRACT:

Purpose

To determine whether the complement factor H (CFH) tyrosine 402 histidine (Y402H) variant, recently shown to be associated with age-related macular degeneration (AMD) and multifocal choroiditis, is associated with specific ocular sarcoidosis clinical phenotypes in black and white persons.

Design

Case-control study.

Methods

The CFH Y402H polymorphism (rs1061170) was genotyped in 41 subjects with ocular sarcoidosis and 393 control subjects. Allele frequencies in the ocular sarcoidosis cases were compared with controls using chi-square score tests. Genotypic model-based (dominant, recessive, and additive) associations of the rs1061170 allele were tested using multivariate logistic regression. Bayesian information criteria were used to formalize model selection. G

SUBMITTER: Thompson IA 

PROVIDER: S-EPMC5450011 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature