The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments.
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ABSTRACT:
SUBMITTER: Veluchamy JP
PROVIDER: S-EPMC5450018 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments.
Veluchamy John P JP Kok Nina N van der Vliet Hans J HJ Verheul Henk M W HMW de Gruijl Tanja D TD Spanholtz Jan J
Frontiers in immunology 20170531
Natural killer (NK) cells are critical immune effector cells in the fight against cancer. As NK cells in cancer patients are highly dysfunctional and reduced in number, adoptive transfer of large numbers of cytolytic NK cells and their potential to induce relevant antitumor responses are widely explored in cancer immunotherapy. Early studies from autologous NK cells have failed to demonstrate significant clinical benefit. In this review, the clinical benefits of adoptively transferred allogeneic ...[more]
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