Pharmacokinetic Analysis of Dynamic ¹⁸F-Fluoromisonidazole PET Data in Non-Small Cell Lung Cancer.

ABSTRACT: Hypoxic tumors exhibit increased resistance to radiation, chemical, and immune therapies. ¹⁸F-fluoromisonidazole (¹⁸F-FMISO) PET is a noninvasive, quantitative imaging technique used to evaluate the magnitude and spatial distribution of tumor hypoxia. In this study, pharmacokinetic analysis (PKA) of ¹⁸F-FMISO dynamic PET extended to 3 h after injection is reported for the first time, to our knowledge, in stage III-IV non-small cell lung cancer (NSCLC) patients. Methods: Sixteen patients diagnosed with NSCLC underwent 2 PET/CT scans (1-3 d apart) before radiation therapy: a 3-min static ¹⁸ F-FDG and a dynamic ¹⁸F-FMISO scan lasting 168 ± 15 min. The latter data were acquired in 3 serial PET/CT dynamic imaging sessio

SUBMITTER: Schwartz J 

PROVIDER: S-EPMC5450365 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature