Ontology highlight
ABSTRACT:
SUBMITTER: Kim K
PROVIDER: S-EPMC5450544 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Kim Kyuri K Leutou Alain S AS Jeong Haein H Kim Dayoung D Seong Chi Nam CN Nam Sang-Jip SJ Lim Kyung-Min KM
Marine drugs 20170513 5
Bioactivity-guided isolation of a crude extract from a culture broth of Bacillus sp. has led to the isolation of (-)-4-hydroxysattabacin (1). The inhibitory effect of (-)-4-hydroxysattabacin (1) was investigated on melanogenesis in the murine melanoma cell line, B16F10, and human melanoma cell line, MNT-1, as well as a pigmented 3D-human skin model. (-)-4-Hydroxysattabacin treatment decreased melanin contents in a dose-dependent manner in α-melanocyte stimulating hormone (α-MSH)-stimulated B16F1 ...[more]