Ontology highlight
ABSTRACT:
SUBMITTER: Quail DF
PROVIDER: S-EPMC5450629 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Quail Daniela F DF Bowman Robert L RL Akkari Leila L Quick Marsha L ML Schuhmacher Alberto J AJ Huse Jason T JT Holland Eric C EC Sutton James C JC Joyce Johanna A JA
Science (New York, N.Y.) 20160501 6288
Macrophages accumulate with glioblastoma multiforme (GBM) progression and can be targeted via inhibition of colony-stimulating factor-1 receptor (CSF-1R) to regress high-grade tumors in animal models of this cancer. However, whether and how resistance emerges in response to sustained CSF-1R blockade is unknown. We show that although overall survival is significantly prolonged, tumors recur in >50% of mice. Gliomas reestablish sensitivity to CSF-1R inhibition upon transplantation, indicating that ...[more]