Discovery and characterization of the tuberculosis drug lead ecumicin.
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ABSTRACT:
SUBMITTER: Gao W
PROVIDER: S-EPMC5450905 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
Discovery and characterization of the tuberculosis drug lead ecumicin.
Gao Wei W Kim Jin-Yong JY Chen Shao-Nong SN Cho Sang-Hyun SH Choi Jongkeun J Jaki Birgit U BU Jin Ying-Yu YY Lankin David C DC Lee Ji-Ean JE Lee Sun-Young SY McAlpine James B JB Napolitano José G JG Franzblau Scott G SG Suh Joo-Won JW Pauli Guido F GF
Organic letters 20141119 23
The new tuberculosis (TB) lead ecumicin (1), a cyclic tridecapeptide, was isolated from Nonomuraea sp. MJM5123, following a high-throughput campaign for anti-TB activity. The large molecular weight of 1599 amu detected by LC-HR-MS precluded the initial inference of its molecular formula. The individual building blocks were identified by extensive NMR experiments. The resulting two possible planar structures were distinguished by LC-MS(2). Determination of absolute configuration and unambiguous s ...[more]
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