Ontology highlight
ABSTRACT:
SUBMITTER: Bosveld F
PROVIDER: S-EPMC5450930 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Bosveld Floris F Markova Olga O Guirao Boris B Martin Charlotte C Wang Zhimin Z Pierre Anaëlle A Balakireva Maria M Gaugue Isabelle I Ainslie Anna A Christophorou Nicolas N Lubensky David K DK Minc Nicolas N Bellaïche Yohanns Y
Nature 20160217 7591
The orientation of cell division along the long axis of the interphase cell--the century-old Hertwig's rule--has profound roles in tissue proliferation, morphogenesis, architecture and mechanics. In epithelial tissues, the shape of the interphase cell is influenced by cell adhesion, mechanical stress, neighbour topology, and planar polarity pathways. At mitosis, epithelial cells usually adopt a rounded shape to ensure faithful chromosome segregation and to promote morphogenesis. The mechanisms u ...[more]