Mannose-binding lectin-deficient genotypes as a risk factor of pneumococcal meningitis in infants.

ABSTRACT:

Objectives

The objective of this study was to evaluate to evaluate the role of mannose-binding-lectin deficient genotypes in pneumococcal meningitis (PM) in children.

Methods

We performed a 16-year retrospective study (January 2001 to March 2016) including patients ≤ 18 years with PM. Variables including attack rate of pneumococcal serotype (high or low invasive capacity) and MBL2 genotypes associated with low serum MBL levels were recorded.

Results

Forty-eight patients were included in the study. Median age was 18.5 months and 17/48 episodes (35.4%) occurred in children ≤ 12 months old. Serotypes with high-invasive disease potential were identified in 15/48 episodes (31.2%). MBL2 deficient genotypes accounted for 18.8% (9/48). Children ≤ 12 months old had a 7-fold ri

SUBMITTER: Bautista-Rodriguez C 

PROVIDER: S-EPMC5451051 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature