Ontology highlight
ABSTRACT:
SUBMITTER: Albritton SE
PROVIDER: S-EPMC5451215 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Albritton Sarah Elizabeth SE Kranz Anna-Lena AL Winterkorn Lara Heermans LH Street Lena Annika LA Ercan Sevinc S
eLife 20170530
In many organisms, it remains unclear how X chromosomes are specified for dosage compensation, since DNA sequence motifs shown to be important for dosage compensation complex (DCC) recruitment are themselves not X-specific. Here, we addressed this problem in <i>C. elegans</i>. We found that the DCC recruiter, SDC-2, is required to maintain open chromatin at a small number of primary DCC recruitment sites, whose sequence and genomic context are X-specific. Along the X, primary recruitment sites a ...[more]