Ontology highlight
ABSTRACT:
SUBMITTER: Shin YH
PROVIDER: S-EPMC5451230 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20170515 6
Following migration of primordial germ cells to the genital ridge, oogonia undergo several rounds of mitotic division and enter meiosis at approximately E13.5. Most oocytes arrest in the dictyate (diplotene) stage of meiosis circa E18.5. The genes necessary to drive oocyte differentiation in parallel with meiosis are unknown. Here, we have investigated whether expression of spermatogenesis and oogenesis bHLH transcription factor 1 (Sohlh1) and Sohlh2 coordinates oocyte differentiation within the ...[more]