Ontology highlight
ABSTRACT:
SUBMITTER: Nayar U
PROVIDER: S-EPMC5451239 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Nayar Utthara U Sadek Jouliana J Reichel Jonathan J Hernandez-Hopkins Denise D Akar Gunkut G Barelli Peter J PJ Sahai Michelle A MA Zhou Hufeng H Totonchy Jennifer J Jayabalan David D Niesvizky Ruben R Guasparri Ilaria I Hassane Duane D Liu Yifang Y Sei Shizuko S Shoemaker Robert H RH Warren J David JD Elemento Olivier O Kaye Kenneth M KM Cesarman Ethel E
The Journal of clinical investigation 20170515 6
Primary effusion lymphoma (PEL) is a largely incurable malignancy of B cell origin with plasmacytic differentiation. Here, we report the identification of a highly effective inhibitor of PEL. This compound, 6-ethylthioinosine (6-ETI), is a nucleoside analog with toxicity to PEL in vitro and in vivo, but not to other lymphoma cell lines tested. We developed and performed resistome analysis, an unbiased approach based on RNA sequencing of resistant subclones, to discover the molecular mechanisms o ...[more]