Ontology highlight
ABSTRACT:
SUBMITTER: Gasparetto M
PROVIDER: S-EPMC5451337 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Gasparetto Maura M Pei Shanshan S Minhajuddin Mohammad M Khan Nabilah N Pollyea Daniel A DA Myers Jason R JR Ashton John M JM Becker Michael W MW Vasiliou Vasilis V Humphries Keith R KR Jordan Craig T CT Smith Clayton A CA
Haematologica 20170309 6
Aldehyde dehydrogenase 1A1 (ALDH1A1) activity is high in hematopoietic stem cells and functions in part to protect stem cells from reactive aldehydes and other toxic compounds. In contrast, we found that approximately 25% of all acute myeloid leukemias expressed low or undetectable levels of ALDH1A1 and that this ALDH1A1<sup>-</sup> subset of leukemias correlates with good prognosis cytogenetics. ALDH1A1<sup>-</sup> cell lines as well as primary leukemia cells were found to be sensitive to treat ...[more]