Serum miRNA signature diagnoses and discriminates murine colitis subtypes and predicts ulcerative colitis in humans.
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ABSTRACT:
SUBMITTER: Viennois E
PROVIDER: S-EPMC5451415 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
Serum miRNA signature diagnoses and discriminates murine colitis subtypes and predicts ulcerative colitis in humans.
Viennois Emilie E Zhao Yuan Y Han Moon Kwon MK Xiao Bo B Zhang Mingzhen M Prasad Meena M Wang Lixin L Merlin Didier D
Scientific reports 20170531 1
Inflammatory bowel disease (IBD) is difficult to diagnose due to nonspecific and variable symptoms, and lack of reliable diagnostic tests. Current methods are invasive, non-sensitive, non-predictive, and do not easily discriminate between its two main forms. Consequently, there remains a great need for reliable serum markers for IBD. Here, using a longitudinal study of various mouse models of colitis, we identified a serum miRNA signature that indicated the development of colitis and discriminat ...[more]
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