Ontology highlight
ABSTRACT:
SUBMITTER: Krater M
PROVIDER: S-EPMC5451425 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Kräter Martin M Jacobi Angela A Otto Oliver O Tietze Stefanie S Müller Katrin K Poitz David M DM Palm Sandra S Zinna Valentina M VM Biehain Ulrike U Wobus Manja M Chavakis Triantafyllos T Werner Carsten C Guck Jochen J Bornhauser Martin M
Scientific reports 20170531 1
The bone marrow (BM) microenvironment provides critical physical cues for hematopoietic stem and progenitor cell (HSPC) maintenance and fate decision mediated by cell-matrix interactions. However, the mechanisms underlying matrix communication and signal transduction are less well understood. Contrary, stem cell culture is mainly facilitated in suspension cultures. Here, we used bone marrow-mimetic decellularized extracellular matrix (ECM) scaffolds derived from mesenchymal stromal cells (MSCs) ...[more]