Role of renal transporters and novel regulatory interactions in the TAL that control blood pressure.

ABSTRACT: Hypertension (HTN), a major public health issue is currently the leading factor in the global burden of disease, where associated complications account for 9.4 million deaths worldwide every year. Excessive dietary salt intake is among the environmental factors that contribute to HTN, known as salt sensitivity. The heterogeneity of salt sensitivity and the multiple mechanisms that link high salt intake to increases in blood pressure are of upmost importance for therapeutic application. A continual increase in the kidney's reabsorption of sodium (Na⁺) relies on sequential actions at various segments along the nephron. When the distal segments of the nephron fail to regulate Na⁺, the effects on Na⁺ homeostasis are unfavorable. We propose that the specific nep

SUBMITTER: Graham LA 

PROVIDER: S-EPMC5451551 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature